Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1989-08-11
1993-10-19
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 88, A61K 3902, A61K 3900
Patent
active
052543404
ABSTRACT:
The invention relates to a vaccine suitable for the prophylaxis and control respectively of Haemophilus pleuropneumoniae, advantageously of all the serotypes of H. pleuropneumoniae, which vaccine is based on an effective content of a mixture of extracellular proteinaceous material derived from the culture medium of strains of at least two different serotypes of H. pleuropneumoniae preferably derived from the culture medium of at least one H. pleuropneumoniae strain selected from the group of serotypes 1,5,6,9 and 11 on the one hand and from the culture medium of at least one H. pleuropneumoniae strain selected from the group of serotypes 2, 3, 4 and 8 on the other hand.
REFERENCES:
Frey et al. FEMS Microbiology Letters 55:41-46 1988.
Maudsley et al., Canadian Journal of Microbiology 32:801-805, 1986.
Rosendal et al., Am J Vet Res-vol. 49 Jul. 1988, Evaluation of heat-sensitive, neutrophil-toxic, and hemolytic activity of Haemophilus (Actinobacillus) pleuropneumoniae pp. 1053-1058.
Lenser et al. (abstract) Vet Microbiology pp. 335-338. Protection of mice against the lethal effect of an intraperitoneal infection with H. (Actinobacillus) pleuropneumoniae.
Nielsen et al. (abstract) Nordisk Veterinaermedicin 1984 pp. 221-234 vol. 36. Haemophilus pleuropneumoniae serotypes-cross protection experiments.
Bloxham (abstract) Irish Veterinary news 1987 vol. 9 pp. 37-38 Preliminary results on the efficacy of a H. pleuropneumoniae vaccine in pigs.
American Society for Microbiology, vol. 87, No. 0, 1987, p. 40, summary No. B-91, U.S.; P. J. Fedorka-Cray et al.
Abstracts of the Annual Meeting of the American Society for Microbiology, (88th Annual Meeting, 8-13 May 1988, Miami Beach, Fla.), vol. 88, No. 0, p. 35, summary No. B-37, P. J. Fedorka-Cray et al.
Kamp Elbarte M.
Van Leengoed Leonardus A. M. G.
Centraal Diergeneeskundig Instituut
Nucker Christine M.
Sidberry H.
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