Vaccine protection assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

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Details

C435S330000, C435S340000, C435S810000

Reexamination Certificate

active

07955817

ABSTRACT:
The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particularN. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningococcus. In order to determine whether a subject or a population is seropositive against invasive meningococcus the SBA test should ideally be both sensitive and specific. The inventors have found the standardN. meningitidisserotype A and W SBAs can be significantly improved in this regard.

REFERENCES:
patent: 2008/0220457 (2008-09-01), De Vleeschauwer et al.
patent: 2004/014417 (2004-02-01), None
patent: 2004/103400 (2004-12-01), None
Susan E. Maslanka, et al.,Standardization and a multilaboratory comparison of Neisseria meningitidis serogroup A and C serum bactericidal assays, Clinical & Diagnostic Laboratory Immunology, vol. 4:2, 156-167 (1997). XP002375515. ISSN: 1071-412X.
D. M. Granoff, et al.,Immunogenicity of an investigational quadrivalent Neisseria meningitidis-diphtheria toxoid conjugate vaccine in 2-year-old children, Vaccine, Butterworth Scientific, Guilford, GB, vol. 23:34, 4307-4314 (Jul. 29, 2005). XP004973252. ISSN: 0264-410X.
K. B. J. Donaldson, et al.,Evaluation of strains and optimal incubation times in Neisseria meningitidis serogroup A and C serum bactericidal assays, Abstracts of the Gen. Meeting of the Am. Soc'y for Microbiology, vol. 95: 0, 293 (1995). XP009064727 & 95thGen. Meeting of the Am. Soc'y for Microbiology, Washington, D.C., USA, May 21-25, 1995. ISSN: 0160-2011.
Y. Almazrou, et al.,Serologic responses to ACYW135 polysaccharide meningococcal vaccine in Saudi children under 5 years of age, Infection & Immunity, vol. 73: 5, 2932-2939 (May 2005). XP002375514. ISSN: 0019-9567.

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