Vaccine preparation comprising a bacterial toxin adjuvant

Details Vaccine preparation comprising a bacterial toxin adjuvant Vaccine preparation comprising a bacterial toxin adjuvant

1989-04-10

1993-01-26

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 424 89, A61K 3902, A61K 3912

Patent

active

051821095

ABSTRACT:
A vaccine preparation comprising in combination a vaccine and a toxin or subunit thereof as an effective component. The toxin is preferably a bacterial toxin, e.g. cholera toxin, staphylococcal .alpha.-hemolysin, staphylococcal .delta.-hemolysin, vibrio thermostable direct hemolysin, pertussis toxin or E. coli heat-labile toxin. The toxin can be a B subunit or a part of a B subunit of a toxin. The vaccine can be influenza vaccine, pertussis vaccine, Japanese encephalitis vaccine, mixed vaccine of pertussis, diphtheria and tetanus toxoid, hepatitis B vaccine, rota vaccine, measles vaccine, rubella vaccine, mumps vaccine, combined vaccine of measles, rubella and mumps, or mycoplasma vaccine. The ratio of vaccine to toxin or subunit thereof is 1:0.0001-1:10,000 (w/v). The vaccine can be intranasal vaccine, or can be in injectable form, spray form or oral administration form.

REFERENCES:
patent: 4440748 (1984-04-01), Graham
patent: 4673574 (1987-06-01), Anderson
patent: 4751064 (1988-06-01), Sela et al.
patent: 4762713 (1988-08-01), Anderson
patent: 4849358 (1989-07-01), Chazono et al.
Schmeerson et al., Infection and Immunity, vol. 45, No. 3, pp. 582-591, Sep. 1984.
Armon et al., Chemical Abstracts, vol. 101, p. 479, Abstract No. 706662, 1984.
Tamura et al., Biological Abstracts, vol. 87, No. 1, Ref. No. 5274.

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