Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1985-02-15
1987-01-13
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Lymphokine
A61K 3915, A61K 39225, A61K 3942
Patent
active
046363858
ABSTRACT:
A live rotavirus vaccine against bovine and human rotaviruses comprising a strain of live bovine rotavirus which does not hemagglutinate primate red blood cells, gives at least about 20 fold higher titers when neutralized with antiserum therefor as compared to heterologous bovine or primate rotaviruses, and has a migration pattern of its RNA genome segments when determined by PAGE substantially as shown by lane WC3 in FIG. 1, the strain of bovine rotavirus having been serially passaged in primate kidney tissue culture a sufficient number of times that when administered to humans the vaccine is immunogenic without causing disease.
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Clark H. Fred
Plotkin Stanley A.
Griffin Ronald W.
The Wistar Institute of Anatomy & Biology
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