Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-05-02
2006-05-02
Housel, James C. (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S023700, C435S069100, C435S069300, C435S235100, C435S320100, C424S184100, C424S186100, C424S189100, C424S204100, C424S227100
Reexamination Certificate
active
07038035
ABSTRACT:
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-'Ś-145 Singapore Strain (Glycine to Arginine) which constituent viral genome is deposited under Accession Nos. P97121504, P97121505 and P97121506 with the European Collection of Cell Culture on 15th Dec. 1997. This invention also provides an isolated nucleic acid encoding a polypeptide which is a mutant major surface antigen of a strain of hepatitis B virus, such polypeptide having an amino acid sequence which differs from the amino acid sequence of a major surface antigen of a wild type hepatitis B virus in that the amino acid at position number 145 of such polypeptide is an arginine rather than a glycine, and the purified peptide. This invention further provides an isolated nucleic acid which encodes a peptide, wherein the peptide is encoded by a nucleic acid molecule comprising nucleotides 527 through 595 of SEQ. ID. No. 1, and the purified peptide. This invention also provides various methods using the disclosed isolated nucleic acids and polypeptides. This invention also provides various uses of the viral strain and its proteins.
REFERENCES:
patent: 5830759 (1998-11-01), Chang et al.
patent: WO91/14703 (1991-10-01), None
patent: 9521189 (1995-08-01), None
patent: 9811916 (1998-03-01), None
Oon et al., Molecular epidemiology of hepatitis B virus vaccine variants in Singapore. Vaccine 13 (8):699-702, 1995.
Ho et al., Clinical and Diagnositic Laboratory Immunology, vol. 2 No 6, pp. 760-762 (Nov. 1995).
Norder et al., Journal of General Viology, vol. 73, pp. 1201-1208 (1992).
Norder et al., Journal of General Viology, vol. 74, pp. 1341-1348 (1993).
Chen Wei Ning
Leong Ai Lin
Lim Gek Keow
Oon Chong Jin
Zhao Yi
Government of Republic of Singapore
Housel James C.
Ladas and Parry LLP
Lucas Zachariah
LandOfFree
Vaccine-induced hepatitis B viral strain and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vaccine-induced hepatitis B viral strain and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccine-induced hepatitis B viral strain and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3624448