Vaccine formulation

Details Vaccine formulation Vaccine formulation

2005-05-10

2005-05-10

Wilson, James O. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S184100, C424S283100, C424S435000, C424S001210, C424S001210

Reexamination Certificate

active

06890540

ABSTRACT:
A vaccine formulation against a microorganism is disclosed. The formulation comprises: as adjuvant, one or more substances selected from a) monoglyceride preparations having at least 80% monoglyceride content and b) fatty acids of the general formula CH3—(CH2)n—COOH where “n” may be varied between 4 and 22, and where the acyl chain may contain one or more unsaturated bonds, and as immunizing component, an immunogenic product consisting of antigenically active carbohydrate moieties (ACM) derived from said microorganism which are each covalently coupled, possibly via identical divalent bridge groups, to immunologically active carriers (IAC). The vaccine formulation is e.g. againstMycobacterium tuberculosisand in that case the formulation may comprise, as adjuvant, a mixture of mono-olein and oleic acid, and possibly soybean oil, and, as immunizing component, lipoarabinomamman-tetanus toxoid (LAM-TT).

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Vercellone et al, Frontiers in Bioscience, Aug. 6, 1998;3:149-63.*
Hansen et al, Ann Surg, Jul. 1976: 184(1):80-88.*
Hamasur et al, Vaccine, 17, 1999, 2853-2861.*
Vercellone et al, Frontiers in Bioscience, Aug. 6, 1998;3:e149-63.

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