Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1997-11-12
1999-01-19
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 71, 435974, 530327, 530328, 530329, 4241861, 4241881, C12Q 170
Patent
active
058612432
ABSTRACT:
Vaccine for protection against HIV infections, therapeutic agents for treatment subsequent to HIV infections, process for their preparation and their use; procedure for differentiation between HIV-2.sub.ALT type infections and HIV-2 infections defined by the prototype HIV-2.sub.ROD.
Subject matter of the present invention are the virus HIV-2.sub.D205 as well as HIV-2 variants distinguishing from the HIV-2 prototypes of the type HIV-2.sub.ROD in that nucleotide sequence homology is less than 77%. Further, proteins and nucleic acids of HIV-2.sub.D205 and its variants for utilization as vaccines for protection against HIV infections, for geno- or immunotherapy, for establishing an animal model, and for differential diagnostics are part of this invention. Furthermore, the processes for preparing these vaccines, immunotherapeutic and diagnostic agents as well as their use are part of this invention.
REFERENCES:
Norley, S. et al. 1992. Immunobiol. vol. 184 pp. 193-207.
Kuhnel, et al, 1989, "Molecular cloning of two West African . . . " PNAS 86: 2383-2387.
Greene, "AIDS and the Immune System" Scientific American, Sep., 1993, pp. 99-105.
Brown, "AIDS Vaccine Trials Viewed With Caution" Washington Post Newspaper, Jun. 10, 1993.
J.F. Zagury et al., "Genetic variability between isolates of human immunodeficiency virus (HIV) . . . " Proc. Natl. Acad. Sci. USA, vol. 85, pp. 5941-5945, Aug. 1988, pp. 5941-5945.
V.M. Hirsch et al., "An African primate lentivirus (SIVsm) closely related to HIV-2", Nature, vol. 339, Jun. 1, 1989, pp. 389-391.
Adamski Michalina
Dietrich Ursula
Kuhnel Herbert
Rubsamen-Waigmann Helga
Von Briesen Hagen
Chemotherapeutisches Forschunginstitut Georg Speyer-Haus Zu Fran
Stucker Jeffrey
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