Vaccine for prophylaxis of trichophytosis in horse and method of

Details Vaccine for prophylaxis of trichophytosis in horse and method of Vaccine for prophylaxis of trichophytosis in horse and method of

1979-01-30

1980-10-21

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 3900

Patent

active

042294347

ABSTRACT:
The invention provides a vaccine for prophylaxis of trichophytosis in the horse which comprises a suspension of microconidia of the immunogenic strain Trichophyton equinum in a sterile physiological salt solution having a pH from 6.2 to 7.0, the concentration of the microconidia ranging from 30 to 45 million microconidia in 1 ml of sterile saline solution. The invention also provides a method for preparing said vaccine for prophylaxis of trichophytosis in the horse which involves growing the immunogenic culture Trichophyton equinum on a solid culture medium at a temperature of 26.degree. to 28.degree. C. for 15 to 25 days until optimum amounts of microconidia of said culture have accumulated, after which the resulting propagated biomass is separated, homogenized to prepare a suspension of separate microorganism cells, and the end product finally isolated by lyophilic drying. The use of the vaccine, prepared by the inventive method, rules out trichophytosis morbidity among horses to abolish losses due to untimely salts of pedigree and sporting horses, and also prevents infection of man. When tested on a mass scale, the vaccine proved highly efficacious (95-98%).

REFERENCES:
Lepper Rev. Med. Vet. Mycol., vol. 6, part 9, pp. 435-446, Mar. 1969 (citing JAKSCH)--"Immunological Aspects of Dermatomycoses in Animals and Man".
V.S.P.T.O. Translation (6/77) of JAKSCH (cited in Lepper, above), "The Diagnosis of Dermatomycosis in Domestic Animals by Means of Allergic Derma Reaction", _(Int. Vet. Cong. Hanover, 1963, vol. 2, pp. 1247-1250).
Petrovich Vot. Bull., 46(5), 2505, May 1976, Abstract of Veterinariya, 10:49-51, (1975), (Agents of Dermatomycosis in Horses (Trichophytum Equinum, T. Gypseum and Microsporium Equinum).
U.S.P.T.O. Translation, (6/77) of Petrovich Veterinariya, 10:49-51, (1975), Agents of Dermatomycosis In Horses.

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