Vaccine for prevention of gram-negative bacterial infections...

Details Vaccine for prevention of gram-negative bacterial infections... Vaccine for prevention of gram-negative bacterial infections...

2005-10-04

2005-10-04

Minnifield, Nita (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S185100, C424S193100, C424S236100, C424S241100, C424S250100, C424S251100, C424S258100, C424S184100, C424S260100, C514S009100, C514S011400, C514S012200, C514S014800, C514S015800, C514S016700, C514S017400, C530S300000, C530S317000, C530S324000, C530S327000, C530S328000, C530S329000, C530S350000

Reexamination Certificate

active

06951652

ABSTRACT:
A vaccine is disclosed which is useful for protecting a host from Gram negative infections and the effects of endotoxin, therefore preventing sepsis and septic shock. The vaccine is prepared by combining LPS free or in conjugate form with a stoichiometric excess of a peptide of the formula:(a) (A)nwherein A is Lysine or Arginine and n is an integer with a minimum value of 7;(b) (AB)mwherein A is Lysine or Arginine and B is a hydrophobic amino acid selected from the group consisting of Valine, Leucine, Isoleucine, Tyrosine, Phenylalanine and Tryptophan; m is an integer with a minimum value of 3; and(c) (ABC)pwherein A is a cationic amino acid which is Lysine or Arginine; B and C are hydrophobic amino acids which may be the same or different and are selected from the group consisting of Valine, Leucine, Isoleucine, Tyrosine, Phenylalanine and Tryptophan; p is an integer with a minimum value of 2.

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