Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2011-04-19
2011-04-19
Minnifield, N. M (Department: 1645)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C435S252330
Reexamination Certificate
active
07927586
ABSTRACT:
Vaccines and methods for making and using the same. An example vaccine may be a vaccine against enterotoxigenicEscherichia coli. The vaccine may include anEscherichia colistrain. TheEscherichia colistrain may produce K88 fimbria and a fusion protein including a mutant LT enterotoxin linked with a STb enterotoxin. An example method for producing a vaccine for porcine post-weaning diarrhea may include providing a first strain ofEscherichia coli. The strain may include the eltAB gene and the estB gene. The method may also include amplifying the eltAB gene, mutating the eltAB gene, generating a genetic fusion of the mutant eltAB gene with the estB gene, and transforming a second strain ofEscherichia coliwith the genetic fusion.
REFERENCES:
patent: 4053584 (1977-10-01), Dobrescu et al.
patent: 4157390 (1979-06-01), Parry et al.
patent: 4237115 (1980-12-01), Brinton, Jr.
patent: 4761372 (1988-08-01), Maas et al.
patent: 5891860 (1999-04-01), Heerze et al.
patent: 6019982 (2000-02-01), Clements et al.
patent: 6033673 (2000-03-01), Clements
patent: 6069137 (2000-05-01), Heerze et al.
patent: 6200576 (2001-03-01), Hwong et al.
patent: 6217883 (2001-04-01), Allan et al.
patent: 6296855 (2001-10-01), Hemmen et al.
patent: 6310043 (2001-10-01), Bundle et al.
patent: 6436407 (2002-08-01), Clements et al.
patent: 6440423 (2002-08-01), Clements et al.
patent: 7063852 (2006-06-01), Clements
patent: 7163820 (2007-01-01), Nagy et al.
patent: 7291342 (2007-11-01), Melson et al.
patent: 2002/0146431 (2002-10-01), Allan et al.
Dubreuil et al. Microbiology (1997), 143, 1783-1795.
Dewey et al., “The Impact of Disease on Nursery Pig Production,” Workshop # 7, Amer. Assoc. Swine Practitioners, Indianapolis, pp. 3-11, 2000.
Francis, Ph.D., “EnterotoxigenicEscherichia coliinfection in pigs and its diagnosis,” J. Swine Health Prod. 10, pp. 171-175, 2000.
Francis, PhD., et al. “Evaluation of a live avirulentEscherichia colivaccine for K88+, LT+ enterotoxigenic colibacillosis in weaned pigs,” Am. J. Vet. Res., vol. 52, pp. 1051-1055, 1991.
Francis et al., “Expression of Mucin-Type Glycoprotein K88 Receptors Strongly Correlates with Piglet Susceptabilty to K88+ EnterotoxigenicEscherichia coli, but Adhesion of This Bacterium to Brush Borders Does Not,” Infect. Immun, vol. 66, pp. 4050-4055, Sep. 1998.
Frantz et al., “Production and Testing ofEscherichia coli(LTb) Toxoid,” pp. 500-517, In: Acres S. (ed.), Fourth International Symposium on Neonatal Diarrhea. Saskatoon, Saskatchewan, CA., 1983.
Frydendahl, “Prevalence of serogroups and virulence genes inEscherichia coliassociated with post weaning diarrhoea and edema disease in pigs and a comparison of diagnostic approaches,” Vet. Microbiol., vol. 85, pp. 169-182, 2002.
Hampson, “PostweaningEscherichia coliDiarrhoea in Pigs,” pp. 171-191 in C.L. Gyle (ed.)Escherichia coliin domestic animals and human., CAB Internatioanl, Oxon, UK, 1994.
Tubbs et al. “Reweaning Morbidity and Mortality in the United States Swine Herd,” Swine Health Prod., vol. 1, pp. 21-38, 1993.
Zhang et al. “Significance of Heat-Stable and Heat-Labile Enterotoxins in Porcine Colibacillosis in an Additive Model for Pathogenicity Studies,”Infect. Immun., vol. 74(6), pp. 3107-3114, Jun. 2006.
Berberov et al., “Relative Importance of Heat-Labile Enterotoxin in the Severe Diarraheal Disease in the Gnotobiotic Piglet Model by a Strain of EnterotoxigenicEscherichia coliThat Produces Multiple Enterotoxins,”Infect. Immun., vol. 72(7), pp. 3914-3924, Jul. 2004.
Friendship, “Swine Research at Guelph: Exploring alternatives to Antibiotics,” Abstract and Introduction, London Swine Conference, Conquering the Challenges, Apr. 11-12, 2002, 1 pg.
Zhang et al., Prevalence of virulence genes inEscherichia colistrains recently isolated from young pigs with diarrhea in the US, Vet. Microbiol., vol. 123, pp. 145-152, 2007.
Francis David
Zhang Weiping
Gangle Brian J
Lane & Waterman LLP
Minnifield N. M
South Dakota State University
LandOfFree
Vaccine for porcine post-weaning diarrhea caused by... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vaccine for porcine post-weaning diarrhea caused by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccine for porcine post-weaning diarrhea caused by... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2710235