Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-05-17
1997-03-04
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4352528, 4353201, 536 231, C12P 2102, C07H 2104, C12N 121, C12N 1563
Patent
active
056078463
ABSTRACT:
Compositions comprising outer membrane protein "E", and peptides and oligopeptides thereof, of Moraxella catarrhalis are described. Additionally, nucleotide sequences encoding the protein, peptide, or oligopeptide are disclosed, as well as recombinant vectors containing these sequences. Protein, peptide, or oligopeptide can be produced from host cell systems containing these recombinant vectors. Peptides and oligopeptides can also be chemically synthesized. Disclosed are the uses of the protein, peptides and oligopeptides as antigens for vaccine formulations, and as antigens in diagnostic immunoassays. The nucleotide sequences are useful for constructing vectors for use as vaccines for insertions into attenuated bacteria in constructing a recombinant bacterial vaccine and for inserting into a viral vector in constructing a recombinant viral vaccine. Also described is the use of nucleotide sequences related to the gene encoding E as primers and/or probes in molecular diagnostic assays for the detection of M. catarrhalis.
REFERENCES:
Sambrook et al. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Press, Cold Spring Harbor).
Murphy et al., "Surface-Exposed and Antigenically Conserved Determinants of Outer Membrane Proteins of Branhamella catarrhalis",Infection and Immunity, vol. 57, No. 10, Oct. 1989, pp. 2938-2941.
Bhushan Reva
Murphy Timothy F.
Guzo David
Research Foundation of State University of New York
Schwartzman Robert
LandOfFree
Vaccine for moraxella catarrhalis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vaccine for moraxella catarrhalis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccine for moraxella catarrhalis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2145423