Vaccine for Moraxella catarrhalis

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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530350, A61K 3902, C07K 1400

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active

059484128

ABSTRACT:
Compositions comprising outer membrane protein "E", and peptides and oligopeptides thereof, of Moraxella catarrhalis are described. Additionally, nucleotide sequences encoding the protein, peptide, or oligopeptide are disclosed, as well as recombinant vectors containing these sequences. Protein, peptide, or oligopeptide can be produced from host cell systems containing these recombinant vectors. Peptides and oligopeptides can also be chemically synthesized. Disclosed are the uses of the protein, peptides and oligopeptides as antigens in antigenic formulations for vaccine applications or for generating antisera of diagnostic or therapeutic use; and as antigens in diagnostic immunoassays. The nucleotide sequences are useful for constructing vectors for use as vaccines for insertions into attenuated bacteria in constructing a recombinant bacterial vaccine and for inserting into a viral vector in constructing a recombinant viral vaccine. Also described is the use of nucleotide sequences related to the gene encoding E as primers and/or probes in molecular diagnostic assays for the detection of M. catarrhalis.

REFERENCES:
Bartos et al. (Oct. 1988) comparison of the outer membrane proteins of 50 strains of Branhamella catarrhalis. J. Infect. Dis. 158:761-765.
Bhushan et al. (Jul. 1991) Molecular characterization of outer membrane protein E of Branhamella catarrhalis: a potential vaccine candidate. Abstracts Gen. Meet. Am. Soc. Microbiol. 97:30.
Maciver et al. (Aug. 1993) Effect of immunization on pulmonary clearance of Moraxella catarrhalis in an animal model. J. Infect. Dis. 168:469-472.

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