Vaccine for infectious bovine rhinotracheitis

Details Vaccine for infectious bovine rhinotracheitis Vaccine for infectious bovine rhinotracheitis

1980-05-02

1981-09-22

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

435235, 435236, 435238, 435239, A61K 39265

Patent

active

042910196

ABSTRACT:
A vaccine for infectious bovine rhinotracheitis (IBR) is prepared by non-ionic detergent extraction of IBR virus infected cells. The extracted viral envelope protein can be prepared in injectable dose form by combination with an oil-type adjuvant. The vaccine produces a high level of antibody response, and is capable of eliminating virus shed for animals infected after immunization.

REFERENCES:
patent: 4158054 (1979-06-01), Furminger et al.
Lupton et al., Am. J. Vbt. Res., 41 (3): 383-390, Mar. 1980, Evaluation of Experimental Subunit Vaccines for Infectious Bovine Rhinotracheitis.
Vester Gaard et al., J. Virol. 24 (1): 82-90, Oct. 1977, Crossed Immunoelectrophoretic Studies of the Solubility and Immunogenicity of Herpes Simplex Virus Antigens.
Cappel Arch Virol. 52: 29-35, (1976), Comparison of the Humoral and Cellular Immune Responses After Immunization with Live, Uninactivated Herpes Simplex Virus and a Subunit Vaccine and Efficacy of these Immunizations.
Kaplan et al., Progr. Med. Virol. 21: 1-12 (1975), Excretion of Specific Glycoproteins by Cells Infected with Herpes Simplex Virus, Types 1 and 2.
Buxton et al., Animal Microbiology, vol. 2, Blackwell Sci. Pub. Ltd., Oxford, UK., (1977), pp. 407-427, 737-740, 745-747.

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