Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1987-10-27
1989-11-07
Moskowitz, Margaret
Drug, bio-affecting and body treating compositions
Lymphokine
424 89, 424 91, 424 92, A61K 3900, A61K 3912, A61K 3902
Patent
active
048791130
ABSTRACT:
The present invention is directed to overcoming immunologically mediated nutritional disturbances in pre-ruminant associated with plant protein antigens and to a vaccine therefor. In accordance with the present invention bovine can be fed dietary plant protein, such as soy protein, after being vaccinated in accordance with the vaccine disclosed herein. The regimen comprises administering orally or parenterally to the pre-ruminant bovine an effective amount of the plant protein which is later to be fed to the bovine. After a selected suitable time interval, the bovine then is parenterally administered a second effective amount of said plant protein, thereby permitting the bovine to be fed the dietary plant protein of the vaccine.
REFERENCES:
Barratt et al, "Immunologically Mediated Nutritional Disturbances Associated With Soya Protein Antigens", Proc. Nutr. Soc., vol. 38, pp. 143-150, 1979.
Challocombe et al, "Systemic Tolerance and Secretory Immunity Offer Oral Immunization", J. Exp. Med., vol. 152, pp. 1459-1472, 1980.
Zoppi et al, "Diet and Antibody Response to Vaccinations in Healthy Infants", The Lancet, July 12, 1983, pp. 11-14.
Effect of Soya Protein on Digestive Enzymes, Gut Hormone, and Anti-Soya Antibody Plasma Levels in the Preruminant Calf, Guilloteau, et al., Reprod. Nutr. Develop. 26 (2B), 717-728, 1986.
Immunologically Mediated Nutritional Disturbances Associated with Soya-Protein Antigens, Proc. Nutr. Soc. (1979), 38, 143.
Barratt et al., Immunoglobulin Classes Implicated in Intestinal Disturbances of Calves Associated with Soya Protein Antigens, The Journal of Immunology, (1979), 123 (2):676-680.
Tomsai, Oral Tolerance, Transplantation, vol. 29, No. 5, 353-356 (1980).
Challacombe et al., Systemic Tolerance and Secretory Immunity After Oral Immunization, J. Exp. Med., vol. 152, 1459-1472 (Dec. 1980).
Walker, et al., The Effect of Pancreatic Duct Ligation on the Breakdown of Antigen an Antigen-Antibody Complexes on the Intestinal Surface, Gastroenterology, vol. 69, No. 6, 1223-1229 (1975).
Andre et al., A Mechanism for the Induction of Immunological Tolerance by Antigen Feeding: Antigen-Antibody Complexes, J. Exp. Med., 142: 1509-1519 (1975).
McGhee et al., The Secretory Immune System, Anal. of the New York Academy of Sciences, vol. 409, pp. 593, et seq., 673 et seq., 650 et seq., and 724, et seq.
Kirk-Othmer, Encyclopedia of Chemical Technology, 3d Ed., vol. 11, pp. 198-207, vol. 19, pp. 332-341; and vol. 21, pp. 432-442; John Wiley & Sons (1980).
Mohamed Abdel A.
Moskowitz Margaret
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