Vaccine for immunizing fish against infectious pancreatic necros

Drug – bio-affecting and body treating compositions – Lymphokine

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424 89, 435 693, A61K 3900

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051659255

ABSTRACT:
A vaccine for simultaneously immunizing large numbers of fish against infection by Infec

REFERENCES:
Caswell-Ruo et al "Monoclonal Antibodies to Infectious Pancreatic Necrosis Virus . . . " J. Gen. Virology v. 67, pp. 2193-2205 (1986).
Mertens & Dobos "Messenger RNA of Infectious Pancreatic Necrosis Virus is Polycioxmic" Nature vol. 297, pp. 243-246, May, 1982.
Duncan et al "Synthesis of the Infectious Pancreatic Necrosis Virus Polyprotein . . . " J. of Virology vol. 61(12) pp. 3655-3664, Dec. 1987.
Dorson, "Infectious Pancreatic Necrosis Virus of Salmonids: Overview of Current Problems," in Antigens of Fish Pathogens (ed. by D. P. Anderson, M. Dorson and P. H. Dubourget) Collection Foundation Marcel Merieux, Lyon, pp. 7-32 (1982).
Okamato et al., Journal of Fish Diseases, 6:19-25 (1983).
Dorson et al., "Infectious Pancreatic Necrosis Virus of Salmonids: Biological and Antigenic Features of a Pathogen Strain and of a Non-pathogenic Variant Selected in RTG-2 Cells," Journal of Fish Diseases, 1:309-320 (1978).
Darragh and MacDonald, "A Host Range Restriction in Infectious Pancreatic Necrosis Virus Maps to the Large RNA Segment and Involves Virus Attachment to the Cell Surface," Virol. 123:264-272 (1982).
Hedrick et al., "Biochemical Characterization of Eel Virus European," J. Gen. Virol. 64:1421-1426 (1983).
Okamoto et al., "Antigenic Relationships of Selected Strains of Infectious Pancreatic Necrosis Virus and European Eel Virus," J. Fish. Dis. 6:19-25 (1983).
Espinoza et al., "Identity Between Infectious Pancreatic Necrosis Virus VR-299 and a Chilean Isolate," Intervirology 24:58-60 (1985).
Somogyi and Dobos, "Virus-Specific RNA Synthesis in Cells Infected by Infectious Pancreatic Necrosis Virus," J. Virol. 33:129-139 (1980).
McAllister and Owens, "Infectious Pancreatic Necrosis Virus: Protocol for a Standard Challenge to Brook Trout," Trans. Amer. Fisheries Soc. 115:466-470 (1986).
MacDonald and Dobos, "Identification of the Proteins Encoded by Each Genome Segment of Infectious Pancreatic Necrosis Virus," Virol. 114:414-422 (1981).
Mertens et al., "In Vitro RNA Synthesis by Infectious Pancreatic Necrosis Virus-Associated RNA Polymerase," J. Gen. Virol. 59:47-56 (1982).
Duncan and Dobos, "The Nucleotide Sequence of Infectious Pancreatic Necrosis Virus (IPNV) dsRNA Segment A Reveals One Large ORF Encoding a Precursor Polyprotein," Nucl. Acids Res. 14:5934 (1986).
Nagy et al., "Mapping of the Large RNA Genome Segment of Infectious Pancreatic Necrosis Virus by Hybrid Arrested Translation," Virol. 158:211-217 (1987).
Huang et al., "A Physical Map of the Viral Genome for Infectious Pancreatic Necrosis Virus Sp: Analysis of Cell-Free Translation Products Derived from Viral cDNA Clones," J. Virol. 60:1002-1011 (1986).
"The Fish Doctors," Oregon Business, p. 127 (Feb. 1988).
Cone, J., "Viral Vaccines for Fish Promising", Oregonian (Thursday, Mar. 23, 1989).
Manning, D. S., "Deletion Mapping and Expression of the Large Genomic Segment of Infectious Pancreatic Necrosis Virus," PhD Thesis, Oregon State University (1988).
Barrie, R. J., "Characterization of an Immunoreactive Region of the Major Capsid Protein for IPNV," Masters Thesis, Oregon State University (1988).

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