Vaccine for diarrhea caused by E. coli

Details Vaccine for diarrhea caused by E. coli Vaccine for diarrhea caused by E. coli

1979-09-04

1981-11-03

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, A61K 39108, A61K 39116

Patent

active

042985978

ABSTRACT:
A relatively safe and effective vaccine for coliform diarrhea and related infections is prepared from semipurified K99 and other concentrated subcellular antigens and organelles of selected. E. coli strains. For this purpose broth cultures of E. coli bacteria are mechanically sheared or sonicated to disrupt the bacterial cells, then centrifuged and the supernatent containing subcellular particles and components is concentrated by ultrafiltration and sterilized by the addition of a preservative and/or stabilizer.

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