Vaccine for cytomegalovirus

Details Vaccine for cytomegalovirus Vaccine for cytomegalovirus

1984-11-02

1987-08-25

Foelak, Morton

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 435235, 435948, A61K 3912

Patent

active

046892257

ABSTRACT:
A novel subunit vaccine employing glycoprotein A of human cytomegalovirus or fragments thereof is provided. The vaccine is particularly suitable for inoculation of immunosuppressed individuals and women of childbearing age to inhibit the transmission of hCMV to the fetus.

REFERENCES:
patent: 3959466 (1976-05-01), Plotkin
patent: 4058598 (1977-11-01), Stern et al.
patent: 4452734 (1984-06-01), Larson et al.
Pereira et al, "Polymorphism of Human Cytomegalovirus . . . MAB", J. Virol., 139, 1984, pp. 73-86.
Pereira et al., Infect. and Imm., vol. 36(3), 1982, pp. 924-942.
Stagno et al, "Congenital Cytomegalovirus Infection", N. Eng. J. Med., vol. 296(22), 1979, pp. 1254-1258.
Starr et al, "Specific Cellular and Humarol Immunity after Immunization . . . Vaccine", J. Inf. Dis., 143(4), 1981, pp. 585-589.
Virology, 2nd Ed., Joklik, 1985, pp. 207-210.
Pereira et al. (1983) Infection and Immunology 39:100-108.

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