Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1979-05-10
1981-04-28
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
A61K 3908
Patent
active
042645883
ABSTRACT:
A vaccine for Clostridium perfringins type E enterotoxemia of rabbits is produced by harvesting (or centrifuging) an actively growing culture of the bacterium and subjecting the supernatant to a proteolytic enzyme to produce a proteinaceous toxin characterized by a molecular weight of from 70,000 to 80,000 daltons, and inactivating the toxin by addition of a fixing agent to produce the toxoid along with any other toxins that might be present.
REFERENCES:
patent: 2719102 (1955-09-01), Baldwin
patent: 3099601 (1963-07-01), Davis et al.
patent: 3288680 (1966-11-01), Sterne
patent: 3579633 (1971-05-01), Thomson
patent: 3983229 (1976-09-01), Relyveld
patent: 4007265 (1977-02-01), Holting
patent: 4029765 (1977-06-01), Holting
Hauschild, A. H. W. Clostridium-perfringens Toxins Types B C D+E Microbial Toxins vol. IIa Bacterial Protein Toxins XIXAcad. Press N.alpha.Y.alpha.1971:159-188.
Marasanova, L. P. ZhMikrobiol Epidemiol Immunobio 148 (8) 1971:116-121 Role of Clostridium-perfringens Types A B C D E+F in the Etiology of Gas Gangrene.
Sharmaeva, S. A. et al. ZhMikrobiol Epidemiol Immunobio 148 (8):58-63 1971, Study of Soluble Clostridium-perfringens Antigens Types D+E on Tissue Culture.
Zemlyanitskaya, E. P. et al. ZhMikrobiol Epidemiol Immunobio 146 (=):57-60 (1969), Effect of Proteolytic Enzymes on the Activity of Proto Toxins Clostridium perfringens Types D+E.
U2 Ermakova et al C.alpha.A.alpha.84:55085w (1976) Morphological Changes in the Cultures of Various Tissues Caused by Clostridium perfringens Toxins type B C D E+F.
Zemlyanitskaya E. P. et al. ZhMikrobiol Epidemiol Immunobio 146 (9):102-105 (1969) Study of Toxin Formation in Clostridium perfringens Type D+E in Dynamics.
Orcutt, R. P. et al. (1978) Clostridium perfringens Type E Enterotoxemia as a cause of acute diarrheal death or "hemorrhagic typlitis" in rabbits Abtract 100 Publication 78-4 Amer. Assoc. Lab Anim. Sci.
Patton, N. M. et al.(1978) Enterotoxemia in Rabbits Lab Anim. Sci. 28:536-540.
Katsaras K Effect of Trypsin and the Method of Injection of the Immunogenic Action of Toxins of Clostridium perfringens Types D+E Vet. Bull. 145 (8) 4238 1975.
McDonel, J. L. et al. Histopathological Effect of Clostridium perfringens Enterotoxin in the Rabbit Ileum Vet. Bull. 46 (4) 1804 (1976).
Rose Shep K.
The Charles River Breeding Laboratories, Inc.
LandOfFree
Vaccine for Clostridium perfringens type E enterotoxemia of rabb does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vaccine for Clostridium perfringens type E enterotoxemia of rabb, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccine for Clostridium perfringens type E enterotoxemia of rabb will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-863967