Vaccine for branhamelia catarrhalis

Details Vaccine for branhamelia catarrhalis Vaccine for branhamelia catarrhalis

1995-12-08

1998-03-10

Minnifield, N. M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4241841, 4242341, 4241851, 530350, 530300, 514 2, 4353201, 4352402, 4352523, 43525411, 435 691, 435 701, 435 711, C07K 1400, C12N 1563, A61K 3900, A61K 39095

Patent

active

057258627

ABSTRACT:
Compositions comprising outer membrane protein "CD", and peptides and oligopeptides thereof, of Branhamella catarrhalis are described. Additionally, nucleotide sequences encoding the protein, peptide or oligopeptide are disclosed, as well as recombinant vectors containing these sequences. Protein, peptide or oligopeptide can be produced from host cell systems containing these recombinant vectors. Peptides and oligopeptides can also be chemically synthesized. Disclosed are the uses of the protein, peptides and oligopeptides as antigens for vaccine formulations, and as antigens in diagnostic immunoassays. The nucleotide sequences are useful for constructing vectors for use as vaccines for insertion into attenuated bacteria in constructing a recombinant bacterial vaccine, and for inserting into a viral vector in constructing a recombinant viral vaccine. Also described is the use of nucleotide sequences related to the gene encoding CD as primers and/or probes in molecular diagnostic assays for the detection of B. catarrhalis.

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