Vaccine for activating helper function of CD8 + Tcells

Details Vaccine for activating helper function of CD8 + Tcells Vaccine for activating helper function of CD8 + Tcells

2008-02-26

2010-02-02

Swartz, Rodney P. (Department: 1645)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

C424S009200, C424S184100, C530S300000, C530S350000

Reexamination Certificate

active

07655216

ABSTRACT:
The invention provides compositions and methods for treating or preventing a target disease in a mammal by induction of memory T cells. The methods comprise (1) administering a sensitizing composition comprising a non-target antigen to a patient; and (2) administering a therapeutic composition comprising a non-target antigen and a target antigen to the patient, wherein the target antigen is associated with the disease, and wherein the therapeutic composition is administered after the sensitizing compositions, at an interval sufficient for induction of memory T cells. The methods can alternatively comprise administering a target antigen along with an inhibitory agent such as an inhibitor of DC apoptosis, an inhibitor of Granzyme B, a Granzyme-B-inducible mediator of apoptosis, an inhibitor of perforin, or a perforin-inducible mediator of apoptosis.

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