Vaccine enhancing the protective immunity to hepatitis c...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S023100, C424S218100, C435S005000

Reexamination Certificate

active

07989425

ABSTRACT:
The present invention relates to a vaccine enhancing the protective immunity to Hepatitis C virus using plasmid DNA and recombinant adenovirus, more particularly to a vaccine consisting of Δ core-E1-E2 expressing DNA vaccine, nonstructural protein NS3 and NS4 expressing DNA vaccine, nonstructural protein NS5 expressing DNA vaccine and recombinant adenovirus vaccine, and method for administration of the vaccine by priming with the DNA vaccines described above and boosting with the recombinant adenovirus vaccine thereby enhancing the protective immunity to Hepatitis C virus.

REFERENCES:
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A: Farci, et al., 1992 “Lack of Protective Immunity Against Reinfection with Hepatitis C”Virus Science258;135-140.
Lechmann, et al., 2000 “Vaccine Development for Hepatitis C”Seminars in Liver Disease20(2):211-226.
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Houghton et al., 2005 “Prospects for a vaccine against the hepatitis C virus”Nature Insights, 436:961-936.

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