Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1996-07-03
1997-10-21
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4242431, 424823, 530326, A61K 3902, A61K 39085
Patent
active
056793499
ABSTRACT:
Peptides derived from proteins associated with bacterial adherence to mammary ductile epithelium are useful in vaccine preparation for preventing mastitis. Methods for determining Microbial adherence provide rational vaccine design.
REFERENCES:
Frost, A. J., Selective Adhesion of Microorganisms to the Ductular Epithelium of the Bovine Mammary Gland. Infection and Immunity, vol. 12, No. 5, pp. 1154-1156, 1975.
Olmsted, S. B. and Norcross, N. L. Bacterial Adherence of Staphylococcus aureus to Bovine Mammary Epithelial Cells in Culture. Abstract 48, International Symposium Virulence Mechanisms of Veterinary Bacterial Pathogens, Iowa State University, 1987.
Olmsted, S. B. and Norcross, N. L. Effect of Specific Antibody on Adherence of Staphylococcus aureus to Bovine Mammary Epithelial Cells, Infection and Immunity, vol. 60, pp. 249-256, 1992.
J.P. Caffin, et al., J. Dairy Sci., 71:2035-2043 (1988) "Physiological and Pathological Factors Influencing Bovine Immunoglobulin G2 Concentration in Milk".
Cafin et al. J. Dairy Science (1983) vol. 66, pp. 2161-2166.
Yancey R. J., Jr. J. Dairy Science (1993) vol. 76, pp. 2418-2436.
Geysen et al J. Molecular Recognition (1988) vol. 1 pp. 32-41.
Mornis et al J. Bacteriology (1985) vol. 164, pp. 255-262.
Scheifinger Curtis C.
Smiley David L.
Boone David E.
Eli Lilly and Company
Gaylo Paula J.
Hutzell Paula K.
Prickril Benet
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