Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1995-07-27
1999-05-04
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
424489, 424490, 424496, 424497, 424 852, 4241851, 4241921, 4241981, 4242781, A61K 3900, A61K 914, A61K 951, A61K 4500
Patent
active
059002387
ABSTRACT:
Compositions comprising an immunogenic amount of an antigen encapsulated in a stabilized hydrogel microbead are disclosed. The compositions provide a delivery system for antigens such as vaccines. Also provided are methods of stimulating an immune response comprising administration of the inventive compositions.
REFERENCES:
patent: 4744933 (1988-05-01), Rha et al.
patent: 5529777 (1996-06-01), Andrianov et al.
patent: 5674495 (1997-10-01), Bowersock et al.
Eldridge et al., "Biodegradable Microspheres: Vaccine Delivery System for Oral Immunization", Current Topics in Microbiology and Immunology 146: 59-66, 1989.
Eldridge et al., "Biodegradable Microspheres As A Vaccine Delivery System", Molecular Immunology 28(3): 287-298, 1991.
Marx et al., "Protection Against Vaginal SIV Transmission with Microencapsulated Vaccine", Science 260: 1323-1327, 1993.
Aguado and Lambert, "Controlled-Release Vaccines -Biodegradable Polylactide/Polyglycolide (PL/PG) Microspheres as Antigen Vehicles", Immunobiology 184: 113-125, 1992.
Offit et al., "Enhancement of Rotavirus Immunogenicity by Microencapsulation", Virology 203: 134-143, 1994.
Bowersock et al., "Evaluation of an Orally Administered Vaccine, Using Hydrogels Containing Bacterial Exotoxins of Pasteurella haemolytica, in Cattle", Am. J. Vet. Res. 55(4): 502-509, 1994.
Mumper et al., "Calcium-Alginate Beads for the Oral Delivery of Transforming Growth Factor-.beta..sub.1 (TGF-.beta..sub.1): Stabilization of TGF-.beta..sub.1 by the Addition of Polyacrylic Acid Within Acid-Treated Beads", Journal of Controlled Release 30: 241-251, 1994.
Puolakkainen et al., "Novel Delivery System for Inducing Quiescence in Intestinal Stem Cells in Rats by Transforming Growth Factor .beta.1", Gastroenterology 107: 1319-1326, 1994.
Singh et al., "Controlled Delivery of Diphtheria Toxoid Using Biodegradable Poly (D,L-Lactide) Microcapsules", Pharmaceutical Research 8 (7): 958-961, 1991.
Brown et al., "Enhancement by Microencapsulation of Rotavirus-Specific Intestinal Immune Responses in Mice Assessed by Enzyme-Linked Immunospot Assay and Intestinal Fragment Culture", Journal of Infectious Diseases 171: 1334-1338, 1995.
Eldridge et al., "Controlled Vaccine Release in the Gut-Associated Lymphoid Tissues. I. Orally Administered Biodegradable Microspheres Target the Peyer's Patches", Journal of Controlled Release 11: 205-214, 1990.
Bowersock et al., "Oral Vaccination of Animals Via Hydrogels", Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 21: 79-80, 1994.
Fanslow, III William C.
Gombotz Wayne R.
Wee Siow Fong
Achutamurthy Ponnathapura
Henry Janis C.
Immunex Corporation
Perkins Patricia Anne
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