Vaccine containing a protein complex form Haemonchus contortus

Details Vaccine containing a protein complex form Haemonchus contortus Vaccine containing a protein complex form Haemonchus contortus

1994-11-21

1998-05-05

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

531350, 531403, A61K 3900, C07K 1400

Patent

active

057470464

ABSTRACT:
A protein complex H45 is described whose components are glycoproteins isolable from the intestinal microvillus plasma membrane of a parasitic nematode, such as Haemonchus contortus. This complex includes protein H4.5, which has an apparent molecular weight on sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) of about 45 Kd under reducing conditions and about 90 Kd under non-reducing conditions, as well as proteins H4.9 and H5.3 which have apparent molecular weights on SDS-PAGE of about 49 Kd and about 53 Kd respectively both under reducing and under non reducing conditions. Protein complex H45 and its components can be used, optionally together with the already known protein doublet H110D, to form a vaccine which can reduce the weight of worms in sheep infected with Haemonchus contortus by an average of 91% and the parasite egg production by an average of 94.5%.

REFERENCES:
Behnke et al, Parisitology Today 3(7): 200-206, 1987.
Hotez et al, Parisitology Today 3(8): 247-249, 1987.
Tavernor et al, Paristology Immunology 14: 645-655, 1992.
Harlow et al "Antibodies a Laboratory Manual", Cold Spring Harbor Labs, NY, 1988, p. 513.
Munn et al, Parasitology 94:385-397, 1987.

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