Vaccine comprising an immunogenic protein and, as an adjuvant, a

Details Vaccine comprising an immunogenic protein and, as an adjuvant, a Vaccine comprising an immunogenic protein and, as an adjuvant, a

1986-08-27

1990-08-07

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

424 86, 424 88, 424 93, 435235, 435236, 435237, A61K 3912, C12N 704

Patent

active

049466763

ABSTRACT:
The invention relates to a new vaccine comprising a native protein capable of inducing the production of protective antibodies in a host, together with an adjuvant amount of certain proteins or peptides which, as such, are not capable of inducing substantial protective antibody titres but considerably enhance the immunizing activity of said native protein.
The amino acid sequences of the adjuvant proteins and peptides show homology with the native proteins. Combination of inactivated picornavirus, such as poliovirus, with adjuvant amounts of denatured picornavirus, such as poliovirus, capsis proteins, in a vaccine, is highly advantageous.

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Van Wezel et al., "Inactivated Poliovirus Vaccine: Current Production Methods and New Developments", Reviews of Infectious Diseases, vol. 6, supplement 2, pp. S335-S340, 1984.
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