Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2005-05-19
2009-08-11
Campell, Bruce (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S009200, C424S185100, C424S204100, C435S005000, C435S106000, C435S236000, C435S456000
Reexamination Certificate
active
07572455
ABSTRACT:
Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Ernsand at least another mutation in the coding sequence for Nprowhich preferably leads to combined inactivation of the RNase activity residing in glycoprotein Ernsin addition to the inactivation of the (hypothesized) immunomodulating activity residing in Npro. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.
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Mayer, Daniel, et al; Attenuation of classical swine fever virus by deletion of the viral Npro gene; Vaccine, 22 (2004); 317,328.
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van Gennip, H.G.P., et al; Experimental non-transmissible marker vaccines for classical swine fever (CSF) by trans-complementation of Erns or E2 of CSFV; Vaccine 20 (2002) 1544-1556.
Ege Andreas
Fetzer Christiane
Meyers Gregor
von Freyburg Martina
Boehringer Ingelheim Vetmedica GmbH
Campell Bruce
Devlin Mary-Ellen M.
Hurt Sharon
Morris Michael P.
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