Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-06-06
1998-01-20
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
4241841, 4242041, 4242341, 424812, 514 2, 514937, 514938, A61K 9127
Patent
active
057098794
ABSTRACT:
A vaccine composition, comprising an antigenic substance in association with a liposome and an oil-in-water emulsion comprising a muramyl peptide, a metabolizable oil, and optionally an additional emulsifying agent. The two components of the adjuvant (i.e., the liposome/antigen component and the emulsion component) act together to produce high levels of immune response.
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Zigterman et al., "Modulation of the Immune Response Against Liposomes Containing Liposoluble Immunogenic Materials," Liposome Technology, 2nd Ed., (.COPYRGT.1993), (Entrapment of Drugs and Other Materials) II(11):185-195.
Barchfeld Gail L.
Ott Gary
Van Nest Gary A.
Blackburn Robert P.
Chiron Corporation
Kishore Gollamudi S.
McClung Barbara G.
Robins Roberta L.
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