Vaccine compositions and methods useful in inducing immune prote

Details Vaccine compositions and methods useful in inducing immune prote Vaccine compositions and methods useful in inducing immune prote

1996-03-15

1998-06-30

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Combination of viral and bacterial antigens

4241841, 4242031, 530300, 530326, 530350, 514 2, 514 4, 514 8, 514 12, A61K 39295, A61K 3800, A61K 39116, A61K 3938

Patent

active

057735700

ABSTRACT:
Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide).

REFERENCES:
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Bonnin, et al., "MHC-Derived Peptides Drive Positive T-Cell Selection in the Thymus: from a Physiological System to an HLA DRB1*0401 Transgenic Mouse Model for Rheumatoid Arthritis?", Assoc. Of Rheumatology Health Professionals, 31st Nat'l. Scientific Meeting, Oct. 1996, pp. S160/Arthritis and Rheumatism, vol. 39, No. 9 suppl. 1996.
Auger, et al., "HLA-DR4 and HLA-DR10 Motifs that Carry Susceptibility to Rheumatoid Arthriis Bind 70-KD Heat Shcok Proteins", Nature Medicine, vol. 2, No. 3, Mar. 1996, pp. 306-310.
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