Vaccine compositions and methods useful in inducing immune prote

Details Vaccine compositions and methods useful in inducing immune prote Vaccine compositions and methods useful in inducing immune prote

1998-06-30

2000-11-28

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Combination of viral and bacterial antigens

4241841, 4242031, 514 2, 514 4, 514 8, 514 12, A61K 39116, A61K 3900, A61K 3938, A61K 3816, A01N 3718

Patent

active

061532002

ABSTRACT:
Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.

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