Vaccine compositions and methods useful in inducing immune...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C536S023700

Reexamination Certificate

active

07094597

ABSTRACT:
Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.

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