Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific...
Patent
1993-09-09
1996-10-08
Housel, James C.
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
4242091, 4242111, 4242171, 4242191, 4242241, 4242251, 4242301, 4242311, 4242441, 4242451, 4242471, 4242541, 4242561, 514169, 514725, 514885, 514171, 514178, 514167, A61K 3900, A61K 3156, A61K 3159
Patent
active
055629105
ABSTRACT:
The invention relates to a vaccine which comprises an antigen and an immune response augmenting agent. The immune response augmenting agent is capable of enhancing T cell lymphokine production. Suitable immune response augmenting agents include, but are not limited to, dehydroepiandrosterone (DHEA) and DHEA-derivatives. Examples of DHEA derivatives include DHEA-sulfate (DHEA-S), 16.alpha.-bromo-DHEA, 7-oxo-DHEA, 16.alpha.-bromo-DHEA-S and 7-oxo-DHEA-S.
The invention also relates to a method for enhancing a vaccine-induced humoral immune response which comprises administering a vaccine which comprises an antigen and an immunomodulator. The immunomodulator may be an immune response augmenting agent, a lymphoid organ modifying agent or a mixture of the immune response augmenting agent and lymphoid organ modifying agent. Suitable lymphoid organ modifying agents include, but are not limited to, 1,25-dihydroxy Vitamin D.sub.3, biologically active Vitamin D.sub.3 derivatives which are capable of activating the intracellular Vitamin D.sub.3 receptor, all trans-retinoic acid, retinoic acid derivatives, retinol, retinol derivatives and glucocorticoid. Alternatively, the method for enhancing a vaccine-induced humoral immune response comprises separately administering the immunomodulator and a vaccine containing an antigen.
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Araneo Barbara A.
Daynes Raymond A.
Housel James C.
Krsek-Staples Julie
University of Utah Research Foundation
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