Vaccine compositions

Details Vaccine compositions Vaccine compositions

1981-06-09

1986-02-04

Rosen, Sam

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 424 89, 435240, 435241, A61K 4100

Patent

active

045685428

ABSTRACT:
The present invention describes the inactivation of target cells by treatment of said cells with psoralens and irradiation with long wave length ultraviolet light. The inactivated cells are shown to be antigenic and are shown to be non-infective. These cells are useful as target antigens for in vitro assays of cellular immunity. Diagnostic kits containing the inactivated, target cells are prepared for use in serologic assays. Since the inactivated cells are immunogenic and non-infective, they are also useful as vaccines.

REFERENCES:
Hanson et al-Chem. Abst., vol. 89 (1978) p. 191,683v.
Hanawalt et al-Chem. Abst., vol. 97 (1982) p. 195174t.
Carlassare et al-Chem. Abst., vol. 88 (1978) 182868m.
Morhenn et al-Chem. Abst., vol. 93 (1980) p. 142760s.
Hood, L. E., Weissman, I. L., and Wood, W. B., Immunology, The Benjamin/Cummings Publishing Co., Inc., pp. 91, 92, 110, 448, 449, 454, (1978).
Cole, R. S., Biochim. Biophys. Acta. 217, 30 (1979).
Colombo, G., et al, Prog. Biochem. Pharmacol., 1, 392 (1965).
Hallick, L., et al, J. Virol., 27, 127 (1978).
Hanson, C., et al, J. Gen. Virol., 40, 345 (1978).
Hearst, J., et al, Nucleic Acids Res. 4, 1339 (1977).
Hochkeppel, H-K, et al, Biochem., 18, 2905 (1979).
Hyde, J., et al, Biochem., 17, 1251 (1978).
Isaacs, S., et al, Biochem., 16, 1058 (1977).
Musajo, L., et al, Experentia, 21, 22 (1965).
Musajo, L., et al, Photochem. Photobiol., 6, 711 and 927 (1967).
Nakashima, K., et al, J. Bio. Chem., 253, 8680 (1978).
Nakashima, K., et al, J. Virol., 32, 838 (1979).
Scott, B., et al, Mut. Res., 39, 29 (1976).
Shen, C-K., et al, Proc. Natl. Acad. Sci. USA, 73, 2649 (1976).
Shen, C-K., et al, J. Mol. Biol., 116, 661 (1977).
Song, P-S., et al, Photchem. Photobiol., 29, 1177 (1979).
Henle, W., et al, J. Exp. Med., 87, 347 (1947).
Hodes, H., et al, Science, 86, 447 (1937).
Howard-Flanders, P., et al, Genetics, 73 (Suppl.), 85 (1973).
Morgan, I., et al, Proc. Soc. Exp. Biol. Med., 47, 497 (1941).
Boyum, A., Scand. J. Clin. Invest., 21 (Suppl. 97), 51 (1968).
Chandler, P., et al, J. Immunol. Methods, 31, 341 (1979).
Cleveland, P., et al, J. Immunol. Methods, 29, 369 (1979).
Coulson, A., et al, The Lancet i, 468 (9164).
Notkins, A., Cell. Immunol. 11, 478 (1974).
Plaeger-Marshall, S., et al, J. Infect. Dis., 138, 506 (1978).
Rosenberg, G., et al, Proc. Natl. Acad. Sci. USA, 69, 756 (1972).
Russell, A., Am. J. Clin. Pathol. 60, 826 (1973).
Sissons, J., et al, J., J. Infect. Dis., 142, 114 (1980).
Zaia, J., et al, J. Infect. Dis., 136, 519 (1977).

Affiliated with

Also associated with

Rating

Vaccine compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vaccine compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccine compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2339866