Vaccine composition comprising interleukin-15 (IL-15)

Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin

Reexamination Certificate

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Details

C530S351000

Reexamination Certificate

active

08007776

ABSTRACT:
Vaccine composition containing IL-15 for active immunization to treatment diseases related to over-expression of this cytokine. The technical aim pursued in this invention is to inhibit IL-15 activity through development of a therapeutic vaccine which elicits IL-15 neutralizing antibodies in the immunized host.IL-15 can be presented in this vaccine composition either alone or coupled to a carrier such as the P64k protein with a vaccine adjuvant such as Aluminum hydroxide.Besides, this invention is related to the use of this vaccine for treatment of Rheumatoid arthritis and other IL-15 over-expressing related diseases, and leukemia, where this cytokine acts as a growth factor.

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Obermeier F, et al. IL-15 protects intestinal epithelial cells. Eur. J. Immunol. 2006. vol. 36, pp. 2691-2699.
Kukita T, et al. Autocrine and/or paracrine growth of adult T-cell leukemia tumour cells by interleukin 15. Br. J. Haematol. 2002. vol. 119, pp. 467-474.
Brewer JM, et al. Aluminum hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling. J. Immunol. 1999. vol. 163, pp. 6448-6454.
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