Vaccine composition comprising herpes simplex virus and...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S231100, C530S300000

Reexamination Certificate

active

06936255

ABSTRACT:
Novel combined vaccine compositions are provided, comprising a herpes simplex virus (HSV) antigen and a HPV antigen and optionally in addition one or more of the following: an EBV antigen, a hepatitis A antigen or inactivated attenuated virus, a hepatitis B viral antigen, a VZV antigen, a HCMV antigen, aToxoplasma gondiiantigen. The vaccine compositions are formulated with an adjuvant which is a preferential stimulator of TH1 cell response such as 3D-MPL and QS21.

REFERENCES:
patent: 5855891 (1999-01-01), Lowy et al.
patent: WO 95/17209 (1995-06-01), None
patent: WO 96/11274 (1996-04-01), None
patent: WO 99/45957 (1999-09-01), None
patent: WO 00/23105 (2000-04-01), None
Chu et al. Journal of Experimental Medicine 1997, vol. 186, No. 10, pp. 1623-1631.
Michel et al. Virology 2002, vol. 294, pp. 47-59.
Roden et al., “Assessment of the SerologicalRelatedness of Genital Human Papillomaviruses by Hemagglutination Inhibition”, Journal of Virology, vol. 70, n0.5, May 1996, pp. 3298-3301.
Wheeler, “Preventive Vaccines for Cervical Cancer”, Salud Publica De Mexico, vol. 39, No. 4, Jul. 1997, pp. 283-287.
Schiller et al., “Papillomavirus-Like Particles and HPV Vaccine Development”, Seminars in Cancer biology, Saunders Scientific Publications, vol. 7, No. 6, pp. 373-382.
Suzich et al., “Systemic immunication with papilomavirus L1 protein completely prevents the development of viral mucosal papillomas”, Proceedings of the National Academy of Sciences of USA, National Academy of Science, vol. 92, 1995, pp. 11553-11557.
Lowe et al., “Human Papillomavirus Type 11 (HPV-11) Neutralizing Antibodies in the Serum and Genital Mucosal Secretions of African Green Monkeys Immunized with HPV-11 Virus-Like Particles Expressed in Yeast”, Journal of Infectious Diseases, vol. 176, No. 5, 1997 pp. 1141-1145.
U.S. Appl. No. 09/807,657, Nathalie Garcon, filed Apr. 16, 2001.

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