Vaccine composition

Details Vaccine composition Vaccine composition

2008-03-18

2008-03-18

Shiao, Rei-tsang (Department: 1626)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C514S078000

Reexamination Certificate

active

10989154

ABSTRACT:
The present invention relates to a pharmaceutical composition comprising at least one vaccine antigen, which also comprises at least one phosphoric ester derivative of phosphatidylcholine having the structure:in which:R1is a lower alkyl,R2and R3are identical or different, and can each represent linear hydrocarbon-based chains having from 13 to 21 carbon atoms.

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Hunang et al., 2006, CAS: 144:127484.
Jiao, X. et al., “Modulation of Cellular Immune Response Against Hepatitis C Virus Nonstructural Protein 3 by Cationic Liposome Encapsulated DNA Immunization”, Hepatology, vol. 37, No. 2, Feb. 2003, 452-460.
Gorman, CM et al., “Efficient in Vivo Delivery of DNA to Pulmonary Cells Using the Novel Lipid EDMPC”, Gene Therapy, vol. 4, No. 9, 1997, 983-992.
MacDonald, Robert C. et al., “Physical and Biological Properties of Cationic Triesters of Phosphatidylcholine”, Biophysical Journal, vol. 77, No. 5, Nov. 1999, 2612-2629.
Rosenzweig, Howard S. et al., “O-Alkyl Dioleoylphosphatidylcholinium Compounds: The Effect of Varying Alkyl Chain Length on Their Physical Properties and In Vitro DNA Transfection Activity”, Bioconjugate Chemistry, vol. 11, No. 3, May 2000, 306-313.

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