Vaccine and method for immunotherapy of neoplastic disease

Details Vaccine and method for immunotherapy of neoplastic disease Vaccine and method for immunotherapy of neoplastic disease

1981-09-30

1988-01-19

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Lymphokine

424 78, A61K 3900, A61K 3174

Patent

active

047203862

ABSTRACT:
A novel vaccine for use in the immunotherapy of neoplastic disease is prepared by a procedure wherein cancerous tissue is surgically removed from a patient to be treated and the tissue is disaggregated into its component cells which are then suspended in water and subjected to hydrodynamic turbulence sufficient to disrupt the cells. The "cell disruption material", possessing cancer-specific antigen, and which comprises cell surface membranes and in some cases also intracellular particles, is mixed with a source of maganous ion (e.g., manganese hydrogen phosphate) and, optionally, a tri-phosphate gel (e.g., manganese tri-phosphate) to produce the vaccine. When inoculated into the patient, the vaccine promotes regression of the cancer through stimulation of the patient's immune response.

REFERENCES:
Spencer, Cancer Research, Part 2, vol. 25, No. 4, May, 1975, p. 963 (4715).
4Dyer, An Index of Tumor Chemotherapy, NIH, 1949, pp. 10 and 30.

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