Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1986-05-02
1990-08-28
Lee, Lester L.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530327, 424 88, 424 89, C07K 708, C07K 710, A61K 3925
Patent
active
049526740
ABSTRACT:
A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. Antibodies directed against peptides imputed from the DNA sequence can react with the glycoprotein, which itself is reactive with neutralizing antibodies. The amino-terminal sequence of the purified glycoprotein is identical to a portion of the amino acid sequence imputed from the DNA sequence. This glycoprotein is useful for the preparation of a vaccine against VZV.
REFERENCES:
patent: 4665159 (1987-05-01), Dobkin
patent: 4686101 (1987-08-01), Ellis et al.
Keller et al., Journal of Virology, vol. 52, No. 1 pp. 293-297,(10/1984).
Welling et al., FEBS Letters vol. 188, No. 2, pp. 215-218 (1985).
Merrifield, Science vol. 232, pp. 341-347 (4/1986).
Keller et al., Chem. Abstr. vol. 101, No. 189532t (1984).
Davison Andrew J.
Ellis Ronald W.
Keller Paul M.
Lowe Robert S.
Riemen Mark W.
Chan Christina
Lee Lester L.
Merck & Co. , Inc.
Perrella Donald J.
Pfeiffer Hesna J.
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