Vaccine against rotavirus diseases and method of preparing same

Details Vaccine against rotavirus diseases and method of preparing same Vaccine against rotavirus diseases and method of preparing same

1987-09-21

1990-05-22

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

424 90, 424 86, 4351723, 435235, 435236, 435237, 435239, 435948, A61K 3912, C12N 1500, C12N 700

Patent

active

049276280

ABSTRACT:
A new method for producing live, attenuated rotavirus strains suitable for preparing a vaccine is described. It is demonstrated that a naturally attenuated rotavirus recovered from newborns or other individuals whos have undergone asymptomatic infection can be used for immunization or that a virulent rotavirus can be converted into an attenuated strain by substituting the conserved fourth rotavirus gene segments of a naturally attenuated rotavirus in the genome of the virulent rotavirus.

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