Vaccine against ricin toxin

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

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4241831, 4241781, A61K 3900, A61K 3938, A61K 39395, A61K 3940, A61K 3942, A61K 4944

Patent

active

054532710

ABSTRACT:
It is now possible to immunize susceptible mammals against the pathological effect of exposure to rice, including inhalation of ricin, by administration of an immunogenic effective amount of ricin toxin sub-units, including subunits of both the A chain and the B chain of the ricin toxin given separately to provide safe, efficacious protection.

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patent: 4689401 (1987-08-01), Ferris
patent: 4962188 (1990-10-01), Frankel
Lemley et al. 1992. Mice are actively immunized after passive monoclonal ibody . . . Immunology 76(3):511-3.
Pincus et al., 1990, Variants selected by treatment of human immunodeficiency virus-infected cells with an immunotoxin, J. Exp. Med., 172:745-757.
Pimm et al, 1989, The influence of syngeneic anti-idiotypic antibody on the biodistribution of an anti-tumour monoclonal antibody in BALB/c mice, Int. J. Cancer, 43(1):147-151.

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