Vaccine against Potomac horse fever and method of preparation th

Details Vaccine against Potomac horse fever and method of preparation th Vaccine against Potomac horse fever and method of preparation th

1986-12-22

1988-07-26

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 92, 435 7, 435 68, 435177, 435188, 435803, 435810, 530806, A61K 39002, A61K 3900, C12N 1106

Patent

active

047599278

ABSTRACT:
A vaccine against Potomac Horse Fever comprises a deactivated E. risticii as the active agent. The agent may be obtained through inoculation of a cell culture, followed through deactivation by exposure to b-propiolactone. The deactivated E. risticii is subsequently isolated and suspended in a pharmaceutically acceptable carrier. Considerable protection against infection is conferred. An assay is also prepared.

REFERENCES:
patent: 4372945 (1983-02-01), Likhite
Robl, Veterinary Medicine, 49-58, (1985).
Holland et al., Science, 227, 522-524, (1985).
Dutta et al., Journal of Clinical Microbiology, 2, 265-269, (1985).

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