Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1990-09-19
1993-01-12
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Lymphokine
5303884, 5303879, 424 88, 43524027, 536 237, A61K 3900, C07K 1528
Patent
active
051788594
ABSTRACT:
The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi.
The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.
REFERENCES:
Barbour, Tessler and Todd, Lyme Disease Spirochetes and Ixodid Tick Spirotes Share a Common Surface Antigenic Determinant Defined by a Monoclonal Antibody, 1983, vol. 41, pp. 795-804.
Johnson, Kodner & Russell, Passive Immunization of Hamster against Experimental Infection with Lyme Disease Spirochete, I & I, vol. 53, 1986, pp. 713-714.
Kochi & Johnson, Role of Immoglobulin G in Killing of Borrelia burgdorferi by the Classical Complement Pathway, Inf. & Imm., vol. 56, pp. 314-321, 1988.
Schaible et al., Proc. Natl. Acad. Sci. 87: 3768-3772 (May 1990).
Eichmann Klaus
Kramer Michael
Reinhard Wallich
Schaible Ulrich E.
Simon Markus M.
Deutsches Krebsforschungszentrum Stiftung des offentlichen Recht
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.v.
Nucker Christine M.
Sidberry H. F.
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