Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1987-02-06
1989-04-04
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 93, 435822, A61K 3902
Patent
active
048185280
ABSTRACT:
A vaccine for immunizing cattle against infectious bovine keratoconjunctivitis which contains protein fragments having an antigenic site common to pili of pathogenic strains of Moraxella bovis and is produced by reacting purified Moraxella bovis pili with cyanogen bromide.
REFERENCES:
patent: 3197373 (1965-07-01), Jackson
patent: 3401219 (1968-09-01), Zeissig
patent: 4254098 (1981-03-01), Graham et al.
patent: 4539201 (1985-09-01), Gwin
patent: 4675176 (1987-06-01), Gerber
A Pilus Peptide Vaccine for the Prevention of Gonorrhea, G. K. Schoolnik, J. Y. Tai, E. C. Gotschlich, Prog. Allergy, vol. 33, pp. 314-331, (Karger, Basel 1983).
The Human Erythrocyte Binding Domain of Gonoccocal Pili, G. K. Schoolnik, J. Y. Tai, E. C. Gotschlich, Bacterial Vaccines, vol. 4, Thieme Slitton, New York, 1982, 172-180.
Cloning and Sequencing of a Moraxella bovis Pilin Gene, Carl F. Marrs, Gary Schoolnik, J. Michael Koomey, Jonathan Hardy, Jonathan Rothbard and Stanley Falkow, Journal of Experimental Medicine, vol. 163, No. 1 pp. 132-139 Jul. 1985.
Gonococcal Pili, Primary Structure and Receptor Binding Domain, Gary K. Schoolnik, Rosemary Fernandez, Joseph Y. Tai, Jonathan Rothbard and E. C. Gotschlich, Journal of Experimental Medicine, vol. 159, May 1984, pp. 1351-1370.
Strain-Specific and Common Epitopes of Gonococcal Pili, Jonathan B. Rothbard, Rosemary Fernandez and Gary K. Schoolnik, Journal of Experimental Medicine, vol. 160, Jul. 1984, pp. 208-221.
Antibodies to Peptides Corresponding to a Conserved Sequence of Gonococcal Pilins Block Bacterial Adhesion (Immunogenicity/syntheticpeptiedes/reverse turns/gonococcal vaccine), Jonathan B. Rothbard, Rosemary Fernandez, Lena Wang, Nelson N. H. Teng, and Gary K. Schoolnik, Proc. Natl. Acad. Sci. U.S.A., vol. 82, Feb. 1985, Microbiology, pp. 915-919.
Pili of Neisseria Menigitidis, David S. Stephens, Anne M. Whitney, Jonathan Rothbard and Gary K. Schoolnik, Journal of Experimental Medicine, vol. 161, Jun. 1985, pp. 1539-1553.
Anigenic Analysis of Gonococcal Pili Using Monoclonal Antibodies, Mark Edwards, Ralph L. McDade, Gary Schoolnik, Jonathan B. Rothbard and Emil C. Gotschlich, J. Ejxp., Copyrighted The Rockefeller University Press, vol. 160, Dec. 1984, pp. 1782-1791.
New Hope for Pinkeye Control, Reprinted with permission from Aug. 1983, Beef, Copyrighted 1983, by Webb Agricultural Publications.
Green Wallace H.
Potgieter Leon N. D.
Schain Howard E.
The University of Tennessee Research Corporation
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