Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1981-10-29
1983-01-04
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 88, A61K 3909, A61K 3900
Patent
active
043672230
ABSTRACT:
Culturing Streptococcus agalactiae in a nutrient broth containing at least 10 g/l of glucose while maintaining the pH at 6-8 by the addition of alkaline material produces polysaccharide antigen including a fraction having a molecular size from 8.varies.11.times.10.sup.5 d. By employing a broth free from constituents having a molecular size above 10.sup.5, the antigens can be separated from the broth in high yield after harvesting the organisms. Vaccination of humans with Streptococcus agalactiae polysaccharide antigens having molecular sizes above 5.times.10.sup.5 produces in selected individuals specific antibody levels above 200 .mu.g/ml of antisera; globulins fractionated from such antisera contain most of the antibody and can be used for passive immunization.
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Hazel Blondel
President and Fellows of Harvard College
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