Vaccine against Gram-negative bacterial infections

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C424S137100, C424S130100, C424S164100, C424S163100, C424S169100, C424S170100, C424S257100, C424S250100

Reexamination Certificate

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07025963

ABSTRACT:
A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived fromE. coliand purified outer membrane protein derived fromN. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.

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