Vaccine against Epstein-Barr Virus

Details Vaccine against Epstein-Barr Virus Vaccine against Epstein-Barr Virus

1984-07-23

1987-11-17

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

514 12, 530350, A61K 39245, A61K 3702, C07K 1300

Patent

active

047073586

ABSTRACT:
The nucleotide sequence of Epstein-Barr Virus (EBV) DNA which codes for outer surface viral proteins has been determined. Fragments of the DNA have been isolated and cloned into a vector which, when placed in a host organism, express proteins which when used to immunize rabbits generate antibody which reacts with the surface proteins of virus infected cells. These proteins are useful for preparation of a vaccine for EBV.

REFERENCES:
Thorley-Lawson et al., Proc. Natl. Acad. Sci., vol. 77, pp. 5307-5311, 1980.
Hoffman et al., Proc. Natl. Acad. Sci., vol. 77, pp. 2979-2983, 1980.
Thorley-Lawson et al., J. Virol., vol. 43, pp. 730-736, 1982.
Hummel et al., J. Virol., vol. 49, pp. 413-417, 1984.
Chemical Abstracts, vol. 94, Abstract No. 137591d, 1981.
Chemical Abstracts, vol. 92, Abstract No. 74191y, 1980.

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