Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2004-08-06
2009-06-02
Minnifield, N. M (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S184100, C424S401000, C424S466000, C424S050000, C424S234100, C424S244100, C424S278100
Reexamination Certificate
active
07541041
ABSTRACT:
This invention is concerned with a vaccine against dental caries obtained from the supernatant over cultures of the cariogenic bacteriaStreptococcus sobrinusandS. mutansthat consists of extracellular proteins. These proteins provide the suppression of the immune response in the host through the early production of IL-10, an anti-inflammatory cytokine and are, for that reason, virulent factors to the microorganism enhancing bacterial load in the host. These proteins were designated as virulence-associated immunomodulatory extracellular proteins (VIP). Vaccination through the host immunization with active VIP in a submitogenis dose, inactivated VIP or enolase in a dose unable to induce immunosuppression, induces the immunoneutralization of the VIP immunobiological effects.Vaccination can be used both as a preventive or therapeutic measure of dental caries as long as it is administered (intranasally, orally or subcutaneously) into mammals before or after bacterial infection, respectively.
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da Conceição Tavares Gomes Maria Delfina
das Neves Ferreira da Silva Paula Maria
de Meneses Moreira da Fonseca António José
Pinto do Amaral Coutinho António Manuel
Rua Vilanova Manuel João
Brinks Hofer Gilson & Lione
Minnifield N. M
UPIN - Universidade Do Porto Inovacao
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