Vaccination against diseases resulting from pathogenic responses

Details Vaccination against diseases resulting from pathogenic responses Vaccination against diseases resulting from pathogenic responses

1993-08-06

1997-03-18

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241841, 530300, 530350, 530395, 530868, A61K 3800, C07K 14725

Patent

active

056120354

ABSTRACT:
The present invention provides vaccines and a means of vaccinating a host so as to prevent or control specific T cell mediated pathologies. The vaccine is composed of a polypeptide whose amino acid sequence corresponds to a segment of the T cell receptor (TCR) present on the surface of the pathogenic T cells. The vaccine is administered to the host in a manner that induces an immune response directed against the TCR of pathologic T cells. This immune response down regulates or deletes the pathogenic T cells, thus ablating the disease pathogenesis. Means of determining an appropriate amino acid sequence for such a vaccine are also provided.

REFERENCES:
patent: 4695459 (1987-09-01), Steinman et al.
patent: 4874845 (1989-10-01), Saito et al.
patent: 4886743 (1989-12-01), Hood et al.
patent: 5114721 (1992-05-01), Cohen et al.
patent: 5223426 (1993-06-01), Skibbens et al.
patent: 5436319 (1995-07-01), Kung et al.
Brostoff, S. W. et al., Annals of the New York Academy of Sciences, vol. 636, pp. 71-78 Dec. 1991.
Brostoff, S. in Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases, J. Bach, editor, Chapter 13, pp. 203-218, "Vaccination with T cell receptor peptides" 1993.
Cohen, I. R., Immunol. Reviews 94;5-21, "Regulation of autoimmune disease physiological and therapeutic" 1986.
Marrack, P. et al., Immunology Today 9:308-315, "T T-cell repertorie for antigen and MHC" 1988.
Hafler, D. A., Immunology Today 17(4):152-159, "TCR usage in human and experimental demyelinating disease" Apr. 1996.
Steinman, L., Annals N. Y. Acad. Sci. 636:147-153, "Prospects for immunotherapy directed to the T cell receptor in human autoimmune disease" 1991.
Vandenbark, A. A. et al., J. Neurosci. Res. 43:391-402, "T cell receptor peptides in treatment of autoimmune disease: rationale and potential" 1996.
Ben-Nun et al., Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein. Nature 292:60-61 (1981).
Acha-Orbea et al., Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263-273 (1988).
Owhashi and Heber-Katz, Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein. J. Exp. Med. 168:2153-2164 (1988).
Burns et al., Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V .alpha. and V .beta. chain genes even though the major histocompatibility complex of encephalitogenic determinants being recognized are different. J. Exp. Med. 169:27-39 (1989).
Chluba et al., T cell receptor .beta. chain usage in myelin basic protein-specific rat T lymphocytes. Eur. J. Immunol. 19:279-284 (1989).
Wucherpfennig et al., Shared human T cell receptor V.beta. usage to immunodominant regions of myelin basic protein. Science 248:1016-1019 (1990).
Yanagi et al., A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature 308:145-149 (1984).
Biddison et al., The germline repertoire of T-cell receptor beta-chain genes in patients with multiple sclerosis. Res. Immunol. 140:212-215 (1989).
Ross et al., Antibodies to synthetic peptides corresponding to variable-region first-framework segments of T cell receptors. Immunol. Res. 8:81-97 (1989).
Schluter et al., Antibodies to synthetic joining segment peptide of the T-cell receptor .beta.-chain: serological cross-reaction between products of T-cell receptor genes, antigen binding T-cell receptors and immunoglobulns. Chem. Abstracts 105(1):464, abstract No. 4767q (1986).
Howell et al., Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246(4930):668-670 (1989).
Patten et al., Structure, expression and divergence of T-cell receptor .beta.-chain variable regions, Nature 312:40-46 (1984).
Kimura et al., Sequences and repertoire of the human T cell receptor .alpha. and .beta. chain variable region genes in thymocytes. Eur. J. Immunol. 17:375-383 (1987).
Sedgwick, J., Long-term depletion of CD8.sup.+ T cells in vivo in the rat: no observed role for CD8.sup.+ (cytotoxic/suppressor) cells in the immunoregulation of experimental allergic encephalomyelitis. Eur. J. Immunol. 18:495-502 (1988).
Urban et al., Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54:577-592 (1988).
Lider et al., Anti-idiotypic network induced by T cell vaccination against experimentall autoimmune encephalomyelitis. Science 239:181-183 (1988).
Sun et al., Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T-T cell interactions. Nature 332:843-845 (1988).
Offner et al., Lymphocyte vaccination against experimental autoimmune encephalomyelitis: evaluation of vaccination protocols. J. Neuroimmunol. 21:13-22 (1989).
Choi et al., Interaction of Staphylococcus aureus toxin "superantigens" with human T cells. Proc. Natl. Acad. Sci. USA 86:8941-8945 (1989).
White et al., The V.beta.-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56:27-35 (1989).
Pullen et al., Identification of the region of T cell receptor .beta. chain that interacts with the self-superantigen Mls-1.sup.a. Cell 61:1365-1374 (1990).
Janeway, C., Self superantigens? Cell 63:659-661 (1990).
Marrack and Kappler, The staphylococcal enterotoxins and their relatives. Science 248:705-711 (1990).
Desquenne-Clark, L., et al., PNAS (USA) 88:7219-7223 (Aug., 1991), "T-Cell receptor peptide immunization leads to enhanced and chronic experimental allergic encelphalomyelitis".
Esch, T., et al., Critical Reviews in Immunology 11(5):249-264 (1992), "Observations, legends and conjectures concerning restricted T-cell receptor usage and autoimmune disease".
Vandenbark, A.A., et al., Nature 341:541-544 (12 Oct. 1989), "Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis".

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