Vaccination against diseases resulting from pathogenic responses

Details Vaccination against diseases resulting from pathogenic responses Vaccination against diseases resulting from pathogenic responses

1993-11-01

1999-01-19

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Cancer cell or component thereof

4241851, 530300, 530350, 530395, A61K 3800

Patent

active

058611649

ABSTRACT:
The present invention provides vaccines and a means vaccinating a host so as to prevent or control specific T cell medicated proliferative diseases. The vaccine is composed of a pharmaceutically acceptable medium and a segment of the T cell receptor (TCR) present on the surface of the T cells mediating the disease. The vaccine is administered to the host in a manner that induces an immune response directed against the TCR of a pathologic T cell. This immune response down regulates or deletes the pathogenic T cells, thus ablating the disease pathogenesis. Means of determining an appropriate amino acid sequence for such a vaccine are also provided.

REFERENCES:
patent: 5612035 (1997-03-01), Howell et al.
patent: 5614192 (1997-03-01), Vandenbark et al.
W.F. Paul (ed), Fundamental Immunology, 3rd edition, pp. 1163-1171, portion of chapter on "Tumor Immunology", 1993.
Sun et al., Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T-T cell interactions. Nature 332:843-845 (1988).
Offner et al., Lymphocyte vaccination against experimental autoimmune encephalomyelitis: evalution of vaccination protocols. J. Neuroimmunol. 21:13-22 (1989).
Choi et al., Interaction of Staphylococcus aureus toxin "superantigens" with human T cells. Proc. Natl. Acad. Sci USA 86:8941-8945 (1989).
White et al., The V.beta.-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56:27-35 (1989).
Pullen et al., Identification of the region of T cell receptor .beta. chain that interacts with the self-superantigen Mls-l.sup.a. Cell 61:1365-1374 (1990).
Janeway, C. Self superantigens? Cell 63:659-661 (1990).
Marrack and Kappler, The staphylococcal enterotoxins and their relatives. Science 248:705-711 (1990).
Yanagi et al., A human T cell-specific cDNA clone encodes a protein having extenstive homology to immunoglobulin chains. Nature 308:145-149 (1984).
Biddison et al., The germline repertoire of T-cell receptor beta-chain genes in patients with multiple sclerosis. Res. Immunol. 140:212-215 (1989).
Ross et al., Antibodies to synthetic peptides corresponding to variable-region first-framework segments of T cell receptors. Immunol. Res. 8:81-97 (1989).
Schluter et al., Antibodies to synthetic joining segment peptide of the T-cell receptor .beta.-chain: serological cross-reaction between products of T-cell receptor genes, antigen binding T-cell receptors and immunoglobulns. Chem. Abstracts 105(1):464, abstract No. 4767q (1986).
Howell et al., Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 246(4930):668-670 (1989).
Vandenbark et al., Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Letters to Nature 341:541-544 (1989).
Patten et al., Structure, expression and divergence of T-cell receptor .beta.-chain variable regions, Nature 312:40-46 (1984).
Ben-Nun et al., Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein. Nature 292:60-61 (1981).
Acha-Orbea et al., Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 54:263-273 (1988).
Urban et al., Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell 54:577-592 (1988).
Owhashi and Heber-Katz, Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T cell receptors specific for myelin basic protein. J. Exp. Med 168:2153-2164 (1988).
Burns et al., Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V .alpha. and V .beta. chain genes even though the major histcompatibility complex of encephalitogenic determinants being recognized are different. J. Exp. Med. 169:27-39 (1989).
Chluba et al., T cell receptor .beta. chain usage in myelin basic protein-specific rat T lymphocytes. Eur. J. Immunol. 19:279-284 (1989).
Wucherpfennig et al., Shared human T cell receptor V.beta. usage to immunodominant regions of myelin basic protein. Science 248:1016-1019 (1990).
Kimura et al., Sequences and repertoire of the human T cell receptor .alpha. and .beta. chain variable region genes in thymocytes. Eur. J. Immunol. 17:375-383 (1987).
Sedgwick, J., Long-term depletion of CD8.sup.+ T cells in vivo in the rat: no observed role for CD8.sup.+ (cytotoxic/ suppressor) cells in the immunoregulation of experimental allergic encephalomyelitis. Eur. J. Immunol. 18:495-502 (1988).
Zamvil et al., Predominant expression of a T cell receptor V.sub..beta. gene subfamily in autoimmune encephalomyelitis, J. Exp. Med. 167:1586-1596 (1988).
Lider et al., Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis. Science 239:181-183 (1988).

Affiliated with

Also associated with

Rating

Vaccination against diseases resulting from pathogenic responses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vaccination against diseases resulting from pathogenic responses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vaccination against diseases resulting from pathogenic responses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1245035