Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-04-17
2007-04-17
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S252330, C435S471000, C536S024100
Reexamination Certificate
active
10089928
ABSTRACT:
Second promoter for mouse and human utrophin genes. The promoters or fragments and derivatives may be used to control transcription of heterologous sequences, including coding sequences of reporter genes. Expression systems such as host cells containing nucleic acid constructs which comprise a promoter as provided operably linked to a heterologous sequence may be used to screen substances for ability to modulate activity of the utrophin promoter. Substances with such ability may be manufactured and/or used in the preparation of compositions such as medicaments. Up-regulation of utrophin expression may compensate for dystrophin loss in muscular dystrophy patients.
REFERENCES:
patent: 5972609 (1999-10-01), Tinsley et al.
patent: 1 033 401 (2000-09-01), None
patent: WO96/34101 (1996-10-01), None
patent: WO 97/22696 (1997-06-01), None
Tubby, B; XP-002160374; Database EMBL Online; Sequence HS91J24, Human DNA Sequence from Clone 91J24 on Chromosome 6q24.
A. et al; A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy;PNAS; vol. 96; No. 24; Nov. 1999; 14025-14030.
Man, Nguyen et al. Full-length and short forms of utrophin, the dystrophin-related protein;FEBS Letters; Jan. 1995; vol. 358 No. 3; Amsterdam, NL.
Burton Edward
Davies Kay
Tinsley Jonathan
Fulbright & Jaworski LLP
Isis Innovation Limited
Ketter James
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