Utrophin gene promoter

Details Utrophin gene promoter Utrophin gene promoter

1999-09-27

2000-07-11

Brusca, John S.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 435325, 536 231, 536 241, C12Q 168

Patent

active

060871113

ABSTRACT:
Mouse and human utrophin gene promoters are provided. The promoters or fragments and derivatives may be used to control transcription of heterologous sequences, including coding sequences of reporter genes. Expression systems such as host cells containing nucleic acid constructs which comprise a promoter as provided operably linked to a heterologous sequence may be used to screen substances for ability to modulate activity of the utrophin promoter. Substances with such ability may be manufactured and/or used in the preparation of compositions such as medicaments. Up-regulation of utrophin expression may compensate for dystrophin loss in muscular dystrophy patients.

REFERENCES:
Kramarcy et al, "Association of utrophin and multiple dystrophin short forms with the mammalian Mr 58,000 dystrophin-associated protein(syntrophin)", J of Biol Chem, Jan. 1994, vol. 269, No. 4, pp. 2870-2876.
Hum. Mol. Genet., vol. 2, No. 11, 1993, pp. 1765-1772, XP002010739 Pearce et al.: "The utrophin and dystrophin genes share similarities in genomic structure" see whole document.
Nature Genetics vol. 6, Mar. 1994, pp. 236-244, XP000578157, Cross et al.: "Purification of CpG islands using a methylated DNA binding column" see whole document.
Database Strand EMBL Empri AN: HS54B8R, Oct. 22, 1995 Mac Donald et al.: see sequence AC :Z61556 (for comparison with seq. ld nr 1 and seq. ld. Nr 3).
Dev. Dynamics vol. 198, Dec. 1993, pp. 254-264, XP000578141 Schofield et al.: "Expression of the dystrophin-related protein (utrophine) gene during mouse embryogenesis" see p. 261-p. 262.
Biotech. Business News, vol. 3, No. 72, Jan. 28, 1994, p. 15 XP000578922 Oncogene Sci. Corpo. et al.: "Muscular dystropy theraphy sought" see abstract.
Nature, vol. 360-593, XP002010740 Tinsley et al.: "Primary structure of dystrophin-related protein" see the whole document.

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